The reduction in the amount and duration of menstrual bleeding in women taking Mirena to treat their idiopathic menorrhagia has been shown to lead to a significant improvement in health-related quality of life and compares well with the surgical alternative of hysterectomy1.
In the study by Hurskainen et al.1 that compared Mirena with hysterectomy in the treatment of menorrhagia over a 5 year period, there was a similarly significant improvement in the 5-dimensional EuroQol (EQ-5D) score in both groups. (The EQ-5D consists of five, 3-level subscales that indicate dimensions of mobility, self-care, usual activities, pain, and mood). When using the RAND-36 survey, which is composed of 8 multi-item dimensions: general health, physical functioning, mental health, social functioning, energy, pain and physical and emotional role functioning, the health-related quality of life (HRQL) scores improved significantly in all dimensions except physical functioning, with no substantial differences between the groups. The anxiety and depression scores also improved significantly, with no substantial difference between the groups (Table 5).
Table 5: Mirena vs. hysterectomy: baseline outcome scores and score changes over 5 years in the two treatment groups1.