Hormonal effects of Mirena
Women may be concerned about the effects of hormones on their body. However, as Mirena does not contain estrogens, estrogen-related hormonal adverse effects should not occur. The most commonly occurring adverse effects, which may be due to levonorgestrel, include headache (occurring in at least 1 out of 10 users) and migrane, depressed mood/depression, nausea, acne and hirsutism (occurring in less than 1 out of 10 users).
For a full list of adverse drug reactions that include those occurring in less than 1 in 10 women, see table 3 in the Mirena: Adverse Effects section (in the Indications for treatment with Mirena section).
Studies have demonstrated that Mirena is not associated with an increased risk of the development of breast cancer 1. Since breast cancer is a hormone-dependent tumor, patients who have breast cancer should use non-hormonal methods of contraception, and breast cancer is a contraindication for Mirena use 2.
- Dinger J,. Bardenheuer K, & Minh TD. Levonorgestrel-releasing and copper intrauterine devices and the risk of breast cancer. Contraception 83 (2011) 211–217.
- Mirena Extended CCDS 2011 Bayer HealthCare Pharmaceuticals, Berlin, Germany, 22nd March 2011.